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Research
Our research focuses on understading how glycosylphosphatidylinositol (GPI) anchors and GPI-anchored proteins are synthesized in eukaryotic cells. In particular, we focus on human cells, where defects in GPI biosynthesis are associated with several neurological diseases, and on parasitic organisms, where GPI anchors play a key role in virulence.
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Our research involves the structural and biochemical investigation of integral membrane enzymes involved in GPI biosynthesis, using a combination of different techniques, including single-particle cryo-EM, X-ray crystallography, in vitro glycolipid assembly, among others.
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